Coordinator: Prof. Dr. Jens Timmer holds a Chair for Theoretical Systems Biology at the Institute of Physics, Albert-Ludwigs University Freiburg and is Director of the School of Life Sciences at the Freiburg Institute for Advanced Studies. He is work package leader in the German Virtual Liver Network, principal investigator of the BMBF-funded MedSys projects BreastSys, SARA, and LungSys and the EU FP 7 STREP CancerSys. In the Helmholtz network SBCancer he collaborates with U. Klingmüller and Thomas Höfer. He is vice-speaker of FRISYS funded by the BMBF. His contributions to systems biology comprise methodological developments, insights in basic research and clinical applications.(Kollmann et al., Nature 2005; Maiwald and Timmer, Bioinformatics 2008; * Raue et al., Bioinformatics 2009; * Becker et al., Science 2010,* Raia et al., Cancer Res 2011)
Prof. Dr. Ursula Klingmüller heads the division Systems Biology of Signal Transduction at the DKFZ Heidelberg and holds the Chair for Systems Biology of Signal Transduction at the University of Heidelberg. As a postdoctoral fellow at the Whitehead Instiute for Biomedical Research in the group of Harvey Lodish she started to address signal transduction through the EpoR and has established herself for more than 15 years as an internationally recognized expert in the field. She coordinates the LungSys consortium and has long-term collaborations with J. Timmer, T. Höfer and H. Busch. She is work package coordinator in the BMBF-funded German Virtual Liver Network as well as member of the management board, is co-coordinator of the Helmholtz Alliance on Systems Biology Network SBCancer, participates in the FORSYS center ViroQuant and the EU network CANCERSYS. She employs data-based mathematical modeling to elucidate dynamic properties of EpoR signaling and the consequences for cellular decisions. In addition, she focuses on standardization of cellular systems and quantitative data generation. (Klingmüller et al., Cell 1995; * Schilling et al., FEBS J 2005; * Schilling et al., Mol Syst Biol 2009; * Becker et al., Science 2010; * Raia et al., Cancer Res 2011)
Dr. Marcel Schilling is scientific project leader in the division and combines experience in quantitative data generation and standardized experimental techniques with mathematical modeling and parameter estimation techniques. His research integrates experimental data and mathematical modeling to uncover general design principles of signaling pathways.
(Klingmüller et al., Cell 1995; * Schilling et al., FEBS J 2005; * Schilling et al., Mol Syst Biol 2009; * Becker et al., Science 2010; * Raia et al., Cancer Res 2011)
Prof. Dr. Thomas Höfer heads the research group Modeling of Biological Systems at the DKFZ Heidelberg. He coordinates the BMBF SysTec consortium EpiSys and the mathematical modeling efforts in the EU-FP7 network SYBILLA (Systems biology of T cell activation). His research focuses on how mammalian cells make differentiation and proliferation decisions and on the interface between cell signaling and genetic regulation. (Schulz et al., Immunity 2009; Brummer et al., PLoS Comput Biol 2010; Busse et al., Proc Natl Acad Sci U S A 2010; Luijsterburg et al., J Cell Biol 2010; Mariani et al., Mol Syst Biol 2010)
Dr. Hauke Busch is a junior fellow at the Freiburg Institute for Advanced Studies (FRIAS), is heading together with Dr. Dr. Melanie Börries a Systems Biology group located at the Freiburg Center for Systems Biology. In their research they are is following an integrated approach to elucidate system properties of cellular decisions and cell-cell communication. They are members of the BMBF-funded consortias MedSys Chronic Wounds and LungSys and is co-coordinating the GerontoSys Stromal Aging consortium. Hauke Busch is an expert in the analysis and modeling of high-throughput transcriptomics data for the establishment of mathematical models to predict and control cellular decisions, which are experimentally performed under supervision of Melanie Börries. (Busch et al., Mol Syst Biol 2008; * Maiwald et al., FEBS J 2010; Riehl et al., BMC Genomics 2010)
Prof. Dr. Anthony D. Ho is chair of the Department of Medicine V (Hematology, Oncology and Rheumatology) of the University Clinical Center of Heidelberg. He is speaker of the DFG-funded collaborative research center SFB 873: Maintenance and Differentiation of Stem Cells in Development and Disease. He has a longstanding expertise in basic stem cell research as well as in developing stem cell based therapies. The Department of Medicine V is representing one of the largest centers for stem cell transplantation in Germany with about 250 autologous and 100 allogeneic stem cell transplantations per year.
Dr. Patrick Wuchter is a resident physician and postdoc scientist at the Department of Medicine V (Hematology, Oncology and Rheumatology) of the University Clinical Center of Heidelberg. His research is focused on the interaction of hematopoietic stem cells with the niche and the impact of this interplay on clinically relevant stem cell functions like homing and mobilization. He is coordinating together with Prof. Dr. Anthony D. Ho the BMBF-funded consortium START-MSC2 (Standardization for Regenerative Therapies Mesenchymal Stem Cells).
(Wagner et al., Blood 2004; Wagner et al., Stem Cells 2005; Wuchter et al., Cell Tissue Res 2007; Ran et al., Exp Hematol 2009; Wuchter et al., Biol Blood Marrow Transplant 2010; Taubert et al., Cytotherapy 2011)
PD Dr. Wolfgang Müller heads the Scientific Databases and Visualistion group at Heidelberg Institute for Theoretical Studies. He coordinates the Virtual Liver Network data management as well as the German part of the SysMO-DB data management project. His interest is providing data management systems that are easy to populate with data and that simplify finding and reusing data once they are stored. (Swainston et al., FEBS J 2010; Drager et al., Bioinformatics 2009)